Detalhe da pesquisa
1.
Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels.
Cell
; 185(25): 4801-4810.e13, 2022 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36417914
2.
Structure-Activity Relationship and Voltage Dependence for the Drug-Drug Interaction between Amiodarone Analogs and MNI-1 at the L-type Cav Channel.
J Pharmacol Exp Ther
; 389(2): 229-242, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38453526
3.
Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat.
J Pharmacol Exp Ther
; 386(1): 26-34, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37068911
4.
Sensitivity, specificity and limitation of in vitro hippocampal slice and neuron-based assays for assessment of drug-induced seizure liability.
Toxicol Appl Pharmacol
; 430: 115725, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34536444
5.
In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase.
Antimicrob Agents Chemother
; 60(8): 4830-9, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27246784
6.
Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells.
Toxicol Appl Pharmacol
; 308: 66-76, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27520758
7.
Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).
Bioorg Med Chem Lett
; 25(17): 3630-5, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26152426
8.
Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).
Bioorg Med Chem Lett
; 25(17): 3636-43, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26141771
9.
Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).
Bioorg Med Chem Lett
; 25(12): 2473-8, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978963
10.
Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4).
Bioorg Med Chem Lett
; 25(11): 2409-15, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25911300
11.
Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Bioorg Med Chem Lett
; 25(9): 1831-5, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25851938
12.
Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability.
J Pharmacol Toxicol Methods
; 123: 107297, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37499956
13.
FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for in vitro pharmacology.
APL Bioeng
; 7(4): 046113, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38046544
14.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866317
15.
Nonclinical safety assessment of the histone deacetylase inhibitor vorinostat.
Int J Toxicol
; 29(1): 3-19, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-19903873
16.
Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation.
Toxicol Sci
; 167(2): 573-580, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365015
17.
Human-induced pluripotent stem cell-derived cardiomyocytes have limited IKs for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker.
JRSM Cardiovasc Dis
; 8: 2048004019854919, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31217965
18.
HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges.
J Pharmacol Toxicol Methods
; 99: 106598, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31201864
19.
Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.
Toxicol Sci
; 170(2): 345-356, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31020317
20.
Response of human induced pluripotent stem cell-derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation.
J Pharmacol Toxicol Methods
; 91: 18-26, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330131